A new solution to deliver chemotherapy: PIPAC
Pressurised intraperitoneal aerosol chemotherapy (PIPAC) is a novel technique to deliver chemotherapy for peritoneal involvement named carcinomatosis – the wide spread of cancer in the body.
By Marc Pocard
The concept of the pressurised intraperitoneal aerosol chemotherapy (PIPAC) technique is to associate an aerosol formation that delivers chemotherapy directly inside the peritoneal cavity during a laparoscopic procedure which enables an increase of drug penetration.
Until now, animal models have confirmed the fact that chemotherapy can reach everywhere in the abdominal cavity. However, no proof exists to show whether the direct action of the drugs on tumors decreases the global dosage with the same effect on tumor progression as high dose on intravenous delivery system.
In their research paper from the journal Pleura and Peritoneum, scientists studied the drugs distribution comparing PIPAC and HIPEC, and its passage from side to side, using the human peritoneum for hernia procedures. In their paper, the researchers reported that the first animal model of PIPAC in mice was able to control the metastatic peritoneal process with a limited chemotherapy dose compared to intravenous treatment.
Using the same model, the scientists demonstrated that detection of a venous platin drug concentration is lower with PIPAC than with the usual intravenous drugs delivery treatment. This paper is the first evidence for efficacy of PIPAC in cancer control on a laboratory experiment model.
Read the original article here
Clarisse Eveno, Aminata Haidara, Ibrahim Ali, Cynthia Pimpie, Massoud Mirshahi, Marc Pocard: Experimental pharmacokinetics evaluation of chemotherapy delivery by PIPAC for colon cancer: first evidence for efficacy. 25.05.2017.