Obesity is a known public health concern and the prevalence of obesity among children and adolescents across the globe is increasing. Researchers have now shown that increased body fat and markers for poor health are associated with higher levels of the protein FABP4.
Together with smoking, experts now say that obesity is once of the modern world’s biggest killers. Ahead of World Obesity Day on 11.10.2017, the World Obesity Federation (WOF) has released new figures stating that by 2025, 2.7 billion adults will be overweight and many will need medical care.
Obese children and adolescents have an increased risk of developing adult obesity and are more likely to experience significant short- and long-term health problems. Studies show that obesity in adolescence has been associated with increased cardiovascular mortality in adulthood.
The adipocyte (fat cell) fatty acid binding protein (FABP4) is not a commonly investigated marker in obesity. It is mainly produced in the body fat and has a wide range of effects ranging from weight-control and metabolism to the formation of atherosclerosis where fatty substances form a deposit of plaque on the inner lining of arterial walls. In adults, FABP4 has been shown to be elevated in patients with obesity, cardiovascular diseases and metabolic syndrome. Yet, very little information exists regarding children.
In a study published in the Journal of Pediatric Endocrinology and Metabolism, scientists assessed the relationships between FABP4 and markers for poor health in a community sample of children over two years. These markers included total body fat, abdominal fat, body fat distribution, aerobic fitness, blood pressure, cardiac dimensions and increase in body fat.
The authors found that children with increased body fat and abdominal fat, more abdominal body fat distribution, lower fitness, larger hearts and increased blood pressure had increased levels of FABP4. A higher increase in total body fat and abdominal fat over a period of two years was also associated with increased levels of FABP4.
The investigation adds information about FABP4 and risk markers for impaired health. Findings from the community-based cohort of young children showed that increased body and abdominal fat as well as low fitness were all associated with increased levels of FABP4.
According to its analysis, the WOF states that without action, the annual cost of treating obesity related diseases worldwide will reach $1.2tn by 2025. The Federation is calling on governments, health service providers, insurers and philanthropic organisations to invest in obesity as a matter of urgency.
Read the original article here:
Magnus Dencker, Anton Danielson, Magnus K. Karlsson, Per Wollmer, Lars B. Andersen, Ola Thorsson: Total body fat, abdominal fat, body fat distribution and surrogate markers for health related to adipocyte fatty acid-binding protein (FABP4) in children, 13.01.2017