A personalised approach to patients’ treatment has been made possible with the advent of new “omics” technologies. These are laboratory diagnostics tailored to individual patients, which is much more effective than traditional diagnostics of a specific disease. Personalised laboratory medicine offers the patient more effective and safer treatments, as well as faster recovery rates.
By Janja Marc
In contrast to classical medical decision making, personalised medicine is based on optimising treatment at the level of an individual patient. The advent of new “omics” technologies which are aimed at the universal detection of genomics (genes), proteomics (proteins) and metabolomics (molecules).
In a recently published review in Clinical Chemistry and Laboratory Medicine, the authors look at the advent of the new “omics” technologies which have enabled the creation of different molecular profiles of individual patients and personalisation of their treatment and maintenance of health.
The goal of personalised laboratory medicine is to use these technologies in the process of preventive, curative or palliative patient management. Personalised laboratory medicine does not rely on changes in concentration of a single molecular marker to make a therapeutic decision, but rather on changes of a profile of markers characterising an individual patient’s status including environmental factors, lifestyle, comorbidities (the presence of one or more diseases co-occurring with a primary disease) etc.
Personalised laboratory medicine takes not only the expected response to treatment of the disease into account, but also the expected response of the patient. Such medical approach promises a more effective and safer treatment, as well as faster recovery and restoration of health and improved cost effectiveness.
The laboratory medicine profession should be aware of its key role in personalised medicine, but if it is to empower the laboratories, an enhancement in cooperation between disciplines within laboratory medicine at individual case (patient) will be necessary.
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Irena Prodan Žitnik, Darko Černe, Irene Mancini, Lisa Simi, Mario Pazzagli, Chiara Di Resta, Helena Podgornik, Barbka Repič Lampret, Katarina Trebušak Podkrajšek, Csilla Sipeky, Ron van Schaik, Ivan Brandslund, Pieter Vermeersch, Matthias Schwab and Janja Marc: Personalized laboratory medicine: a patient-centred future approach. 10.07.2018