Growth hormone deficient children properly treated with recombinant GH attain their final height in accordance with their genetic background. Upon completing their final height, not all individuals continue their status of GH deficiency.
By Luiz De Lacerda
Growth Hormone (GH) is fundamental for acquisition and stability of muscle mass and strength. Adolescents with childhood-onset growth hormone deficiency (GHD) who interrupt their GH treatment upon reaching their final height, present compromised muscle and skeletal peak mass acquisition. This includes reduced isometric muscle strength, increased body fat, an impaired lipid profile, cardiac morphology, and physical performance.
Resistance exercise is critical for muscle development and improves both agonist and antagonist muscle groups. Recombinant GH (rGH) has been used by athletes with the assumption that it can improve their performance. However, it has not been proven that persistent rGH use is accompanied by increment of muscle strength and physical performance.
In a recently published study from the Journal of Pediatric Endocrinology and Metabolism, researchers from Brazil evaluated the impact of a program of resistance exercise on muscle strength in two groups of young male adult individuals. The subjects had all been treated with rGH throughout infancy and adolescence: one group with GHD and the other group with GH sufficiency.
In the second phase of the study, GHD patients performed the program of resistance exercise plus a titrated dose of rGH. A short period of resistance exercise alone was sufficient to improve parameters of muscle strength in young male adults with childhood-onset GHD, while the addition of rGH had no further influence upon them.
Optimistically saying, a very simple tool – resisted exercise, is sufficient to accomplish better muscle condition in patients with GHD, facilitating a cheaper method to improve muscle strength.
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Nadia Mohamad Amer / Marilza J. Modesto / Cláudia Duarte Dos Santos / Oscar Erichsen / Luis P.G. Mascarenhas / Suzana Nesi-França / Rosana Marques-Pereira / Luiz De Lacerda: Resistance exercise alone improves muscle strength in growth hormone deficient males in the transition phase. 27.07.2018